Drug-Resistant Epilepsy

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Despite choosing the correct medications at adequate doses, some children continue to experience ongoing seizures. When sustained seizure freedom is not attained despite trials of 2 or more properly dosed medications, due to lack of efficacy the epilepsy is defined as drug resistant. (53) Children with drug-resistant epilepsy should be referred to a comprehensive epilepsy center to evaluate for possible epilepsy surgery (respective surgery, callosotomy, or neuromodulation [vagus nerve or brain stimulation]) or consideration of additional therapies, including dietary therapies (ketogenic diet, modified Atkins diet, low glycemic index diet).

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