Benzodiazepines 60th Year Anniversary Symposium (1958-2018)

  • Gastaut’s magic bullet: The history of benzodiazepines in epilepsy – Simon Shorvon (United Kingdom)
  • How benzodiazepines’ structure and pharmacokinetics affected their antiepileptic use – Meir Bialer (Israel)
  • The current role of benzodiazepines in epilepsy treatment – Martin Brodie (United Kingdom)
  • Can we develop better benzodiazepines? – Wolfgang Löscher (Germany)

Connectivity in cognitive networks and epileptic networks

  • EEG and fMRI connectivity in epilepsy – Serge Vulliémoz (Switzerland)
  • Altered connectivity in language and memory networks in epilepsy – Silvia Bonelli (Austria)
  • Network connectivity abnormalities in paediatric epilepsy: (trying to) separate transient from longer term network abnormalities – David Carmichael (United Kingdom)
  • Structure-function relationships in epileptic networks: insights from imaging and computational models – Maxime Guye (France)

Enabling precision medicine in epilepsy through big health data analytics

  • Challenges and opportunities of using linked national electronic health records for research – Spiros Denaxas (United Kingdom)
  • Large, linked electronic and administrative data and the epidemiology of epilepsy – Colin Josephson (Canada)
  • Combining large linked national health records with genomics to advance personalised medicine – Ghazaleh Fatemifar (United Kingdom)
  • Rational drug design using precision medicine models – Emilio Perucca (Italy)

Epilepsy and mitochondria

  • Epilepsy due to mitochondrial disease – clinical and genetic diversity – Shamima Rahman (United Kingdom)
  • The interplay of mitochondrial dysfunction and epileptiform discharge activities – Matej Hotka (Austria)
  • Mitochondrial dysfunction and seizures – mechanisms and potential treatment strategies – Wolfram Kunz (Germany)
  • Modelling seizure like metabolic dysfunction in fibroblasts of patients suffering from mitochondrial disease – a screening platform for drug development – Stjepana Kovac (Germany)

Epilepsy and the social brain

  • The social brain – its development, neurology and epilepsy – Stefano Meletti (Italy)
  • Imaging of the social brain – Hrvoje Hecimovic (Croatia)
  • Socio-behavioural side effects of AED and epilepsy surgery – Jana Amlerová (Czech Republic)
  • Remediation of social functioning: Where are we? – Hennric Jokeit (Switzerland)

Epileptic encephalopathies in adulthood: clinical features and personalized therapy

  • Clinical evolution of epileptic encephalopathies: lessons from the paediatric clinic – Pasquale Striano (Italy)
  • Epilepsy and intellectual disability in adulthood: genetic epileptic encephalopathy or structural epilepsy due to birth injury? – Karl Martin Klein (Germany)
  • Investigating adults with epileptic encephalopathies – Sanjay Sisodiya (United Kingdom)
  • Therapeutic implications and precision medicine: is there still something to win in adulthood? – Sarah Weckhuysen (Belgium)

Genetics and pharmacogenetics of the epilepsies and their translation into clinical practice

  • New findings in epileptic encephalopathies – Sarah Weckhuysen (Belgium)
  • Gene burden and pharmacogenetics in genetic generalized epilepsies – Holger Lerche (Germany)
  • Genetic variants influencing response to antiepileptic drugs – Sanjay Sisodiya (United Kingdom)
  • Pharmacogenetics of adverse reactions to antiepileptic drugs – Gianpiero Cavalleri (Ireland)

Hot topics in epilepsy surgery

  • Stereotactic approaches to treat hypothalamic hamartomas – Andreas Schulze-Bonhage (Germany)
  • Thermoablation for temporal lobe epilepsy? – Zdeněk Vojtěch (Czech Republic)
  • Laser interstitial thermal therapy in which epilepsy syndrome? – Daniel Curry (USA)
  • Radiosurgery in epilepsy – Andrew McEvoy (United Kingdom)

Ictal source localization – clinical implications and future perspectives

  • High density ictal source localization – what is the benefit? – Margitta Seeck (Switzerland)
  • Automatic ictal source localization – is it feasible? – Christoph Baumgartner (Austria)
  • Ictal source localization on MEG – additional benefits? – Hermann Stefan (Germany)
  • From ictal source localization to connectivity analysis – Pieter van Mierlo (Belgium)

Myths and misbeliefs in the idiopathic generalized epilepsies (IGES)

  • Myth: Basic mechanisms involved in non-convulsive seizures are similar in IGE and focal epilepsies – Antoine Depaulis (France)
  • Myth: The IGEs are all genetic – José Serratosa (Spain)
  • Myth: Drug-resistance in the IGEs is rare – Jukka Peltola (Finland)
  • Myth: There are plenty of treatment options for the IGEs – Pierre Thomas (France)

Neurobehavioral co-morbidities in epilepsy: from mechanisms of vulnerability to predictive biomarkers, and to treatments

  • Depression and cognitive deficits in patients with epilepsy – Nathalie Jette (Canada)
  • Hippocampal rhythmopathies and cognitive co-morbidities in epilepsy – Liset Menendez de la Prida (Spain)
  • Monoaminergic vulnerabilities predicting depression and ADHD in epilepsy – Andrey Mazarati (USA)
  • Oxidative stress and vulnerability to depression and cognitive deficits – Christophe Bernard (France)

Pharmacoresistance and epileptogenesis

  • Epilepsy pharmacoresistance – what are we missing? – Silvio Basic (Croatia)
  • Gene therapies in drug-resistant epilepsies – Matthew Walker (United Kingdom)
  • Epigenetics in pharmacoresistant epilepsy – Katja Kobow (Germany)
  • Pitfalls and obstacles in childhood pharmacoresistant epilepsy – Dana Craiu (Romania)

Prevention strategies to reduce mortality in epilepsy

  • Prevention of SUDEP – Rainer Surges (Germany)
  • Prevention of suicide – Marco Mula (United Kingdom)
  • Prevention of accidents and injuries – Tim von Oertzen (Austria)
  • Prevention of serious adverse events of antiepileptic drugs – Cecilie Johannessen Landmark (Norway)

Rational drug combination for disease prevention and disease-modification by network pharmacology

  • Combination of clinically used drugs for antiepileptogenesis therapies in experimental models – Wolfgang Löscher (Germany)
  • Combinatorial treatments against neuroinflammation and oxidative stress for improving disease outcomes in animal models – Teresa Ravizza (Italy)
  • Systems biology to identify gene networks in human epileptic brain for combinatorial drug discovery – Michael Johnson (United Kingdom)
  • Rational new drug combinations in clinical trials for antiepileptogenesis and disease modifications: is it feasible and how? – Matthias Koepp (United Kingdom)

Seizure detection and quantification: paradigm shift in diagnosis and therapy of epilepsy?

  • Scalp EEG-based seizure detection – Christoph Baumgartner (Austria)
  • Invasive EEG-based seizure detection – Mark Cook (Australia)
  • Non-EEG based seizure detection – Sándor Beniczky (Denmark)
  • Wearable seizure detection devices and SUDEP prevention – Philippe Ryvlin (Switzerland)

Sex matters – also in epilepsy

  • Prevalence and characteristics of sexual dysfunction in patients with epilepsy – Oliver Henning (Norway)
  • Sexual dysfunction in patients with epilepsy: Pathogenic mechanisms – Gerhard Luef (Austria)
  • Doctor, I have lost interest in sex – What to do? – Anneliese Schwenkhagen (Germany)
  • Sexual function after epilepsy surgery – Kurupath Radhakrishnan (India)

Subjective impressions triggered by cortical electrical stimulations

  • Limbic electrical stimulations triggering experiential and emotional phenomena – Andreas Schulze-Bonhage (Germany)
  • Pain as a product of cortical electrical stimulations – Laure Mazzola (France)
  • Autoscopic phenomena induced by electrical stimulations – Margitta Seeck (Switzerland)
  • Ecstatic auras induced by electrical stimulation – Fabienne Picard (Switzerland)

Teratogenicity of antiepileptic drugs (AEDs)

  • How can we take advantage of contemporary genetic tools to find a genetic signature of susceptibility to use AEDs with greater safety? – Richard Finnell (USA)
  • How the next generation should be developed knowing the problems of the existing AEDs – Meir Bialer (Israel)
  • Juvenile myoclonic epilepsy in pregnancy: Update from EURAP on AED use, seizure control and pregnancy outcome – Torbjörn Tomson (Sweden)
  • Teratogenicity in law court – Simon Shorvon (United Kingdom)

The expansion of ultra-long-term EEG-recordings in the near future

  • Long term EEG monitoring out of the EMU – Pål Larsson (Norway)
  • Long term implantable EEG – Troels Wesenberg Kjær (Denmark)
  • Algorithms for detection of rare seizure events in patients with intellectual disabilities – Johan Arends (Netherlands)
  • The caretakers view: does continuous monitoring lead to more independence? – Maaike Ballieux (Netherlands)

The gut microbiota and epilepsy: is there a link?

  • Why should we become interested in the gut-brain axis in epilepsy? – Astrid Nehlig (France)
  • The microbiota gut-brain axis and neurological disorders – John Cryan (Ireland)
  • Could the antiepileptic effect of the ketogenic diet reflect an action on the gut? – Stéphane Auvin (France)

The role of nodular heterotopia in epileptogenesis: a lesion or network disorder?

  • The pathophysiology of grey matter heterotopia, their involvement in brain cortical development and functional consequences – Alfonso Represa (France)
  • The physiological consequences of abnormal connectivity in patients with grey matter heterotopia – Mouhsin Shafi (USA)
  • Electroclinical characteristics of nodular heterotopia – Fabrice Bartolomei (France)
  • Nodular heterotopia causing refractory seizures: should we target the lesion, the circuit or the cortex? – Laura Tassi (Italy)

The role of thalamus in seizures and treatment in focal epilepsies

  • Methods and concepts to explain the role of thalamus in temporal lobe epilepsy – Hal Blumenfeld (USA)
  • Active role of anterior thalamus in elaboration of focal seizures – Ivan Rektor (Czech Republic)
  • Imaging the thalamus and thalamocortical networks in focal epilepsy: significance for treatment outcome – Simon Keller (United Kingdom)
  • Neurostimulation – clinical experience with various thalamic targets – Friedhelm Carl Schmitt (Germany)

Tuberous sclerosis complex: understanding and modifying epileptogenesis

  • Epilepsy and behaviour in TSC – Paolo Curatolo (Italy)
  • Molecular biomarkers of epileptogenesis – Eleonora Aronica (Netherlands)
  • Clinical (imaging and EEG) biomarkers of epileptogenesis in TSC – Lieven Lagae (Belgium)
  • Early and preventative treatment of epilepsy in TSC to modify neurological outcome – Sergiusz Jozwiak (Poland)

Update on psychogenic nonepileptic seizures

  • Towards an integrated biopsychosocial model of PNES – Markus Reuber (United Kingdom)
  • PNES around the world: an ILAE survey – Coraline Hingray (France)
  • PNES and epilepsy – Sofia Smarkoula (Greece)
  • Psychotherapy for PNES – Rosa Michaelis (Germany)

What cerebrospinal fluid can tell us about epilepsy

  • Biomarker proteins and cytokines in the CSF of epilepsy patients – Peter Körtvelyessy (Germany)
  • Blood-brain barrier dysfunction, seizures and epilepsy – Erwin van Vliet (Netherlands)
  • Autoantibodies in the CSF and their role in epilepsy – Christian Bien (Germany)
  • MicroRNAs as potential biomarkers of epilepsy – David Henshall (Ireland)

VIREPA EEG courses: what and how we can teach you online

  • Basic-EEG: The use and abuse of clinical EEG – Bogdan Lorber (Slovenia)
  • Advanced-EEG: Get more out of your digital EEG recording – Michalis Koutroumanidis (United Kingdom)
  • VIREPA paediatric EEG course – Monika Eisermann (France)